>Contributions >H.O. and Y.S. wrote the manuscript. >H.O., T.W. and Y.S. performed experiments, and K.K. assisted with H.O.’s transplantation experiments. >H.O., T.W., Y.S., H.N. and C.A.V. designed the project. >M.P.V. and M.Y. helped with the design and evaluation of the project.