>>12 Harlequin-type ichthyosis is a genetic disorder which results in thickened skin over nearly the entire body at birth. [4] The skin forms large, diamond-shaped plates that are separated by deep cracks.[4] They affect the shape of the eyelids, nose, mouth, and ears, and limit movement of the arms and legs.[4] Restricted movement of the chest can lead to breathing difficulties.[4] These plates fall off over several weeks.[3] Other complications can include premature birth, infection, problems with body temperature, and dehydration.[4][5]