- 【未来技術】糖質制限全般69【人体実験】
226 ：病弱名無しさん (ｱｳｱｳｳｰ Sa5b-49bV [106.181.151.148])[]：2017/05/30(火) 12:51:25.20 ID:UVk7nBXJa - Both ketones and lactate are converted to Acetyl-CoA intracellularly
, so they can be used for energy metabolism via the TCA cycle and mitochondrial oxidative phophosphoryation.
However, Acetyl-CoA is also utilized for the acetylation of proteins such as histones, which is implicated in the epigenetic regulation of gene expression.
Histone acetylation neutralizes the positive charge on histones, promoting their dissociation from DNA, potentially increasing gene transcription.
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- 【未来技術】糖質制限全般69【人体実験】
227 ：病弱名無しさん (ｱｳｱｳｳｰ Sa5b-49bV [106.181.151.148])[]：2017/05/30(火) 12:52:41.03 ID:UVk7nBXJa - The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma: Cell Cycle: Vol 8, No 23
http://www.tandfonline.com/doi/abs/10.4161/cc.8.23.10238
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- 【未来技術】糖質制限全般69【人体実験】
228 ：病弱名無しさん (ｱｳｱｳｳｰ Sa5b-49bV [106.181.151.148])[]：2017/05/30(火) 12:54:02.01 ID:UVk7nBXJa - The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism: Cell Cycle: Vol 9, No 17
http://www.tandfonline.com/doi/abs/10.4161/cc.9.17.12721
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- 【未来技術】糖質制限全般69【人体実験】
229 ：病弱名無しさん (ｱｳｱｳｳｰ Sa5b-49bV [106.181.151.148])[]：2017/05/30(火) 12:55:37.40 ID:UVk7nBXJa - Next, we assessed whether 3-hydroxy-butyrate or L-lactate can function as chemo-attractants, using a modified “Boyden Chamber” assay, employing Transwell cell culture inserts.
MDA-MB-231 cells were placed in the upper chambers and 3-hydroxy-butyrate
(10 mM) or L-lactate (10 mM) were introduced into the lower chambers. Interestingly, using this assay system, both 3-hydroxy-butyrate and L-lactate promoted cancer cell migration by nearly 2-fold (Fig. 3).
Thus, the metabolic products of aerobic glycolysis can also function as chemo-attractants for cancer cells, probably via a form of nutrient sensing.
https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3047616_cc0917_3506_fig003.jpg
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- 【未来技術】糖質制限全般69【人体実験】
230 ：病弱名無しさん (ｱｳｱｳｳｰ Sa5b-49bV [106.181.151.148])[]：2017/05/30(火) 12:56:49.88 ID:UVk7nBXJa - Ketones and lactate function as chemo-attractants, stimulating cancer cell migration.
We assessed whether 3-hydroxy-butyrate or L-lactate can function as chemo-attractants, using a modified “Boyden Chamber”
assay, employing Transwell cell culture inserts. MDA-MB-231 cells were placed in the upper chambers and 3-hydroxy-butyrate (10 mM) or L-lactate (10 mM) were introduced into the lower chambers.
Note that both 3-hydroxy-butyrate and L-lactate promoted cancer cell migration by nearly 2-fold
. *p < 0.05, control (vehicle alone) versus 3-hydroxy-butyrate or L-lactate (10mM) (Student's t-test).
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- 【未来技術】糖質制限全般69【人体実験】
233 ：病弱名無しさん (ｱｳｱｳｳｰ Sa5b-49bV [106.181.151.148])[]：2017/05/30(火) 13:03:44.21 ID:UVk7nBXJa - http://science.sciencemag.org/content/325/5947/1555?ijkey=8034074e7806a5286489c84d8c627ad8eff07b20&keytype2=tf_ipsecsha
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- 【未来技術】糖質制限全般69【人体実験】
234 ：病弱名無しさん (ｱｳｱｳｳｰ Sa5b-49bV [106.181.151.148])[]：2017/05/30(火) 13:04:27.21 ID:UVk7nBXJa - >>233
Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells | Science
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