- 【未来技術】糖質制限全般68【人体実験】 [無断転載禁止]©2ch.net
958 ：病弱名無しさん (ｱｳｱｳｳｰ Sa07-kpOn [106.181.155.27])[]：2017/05/19(金) 16:16:57.97 ID:2oW6XsuAa - >>957
In brief, this involves the addition of a methyl group along the DNA strand where a cytosine base is located beside a guanine base (CpG site) .
This addition affects the expression of the gene15 and has been shown to prevent protein coding and decrease the expression levels of the gene.14,
Using Sequenom MassARRAY we measured the methylation status of 68 CpGs 5' from five candidate genes in umbilical cord tissue DNA from healthy neonates.
Methylation varied greatly at particular CpGs: for 31 CpGs with median methylation ≥5%
and a 5-95% range ≥10%, we related methylation status to maternal pregnancy diet and to child's adiposity at age 9 years.
Replication was sought in a second independent cohort.
| - 【未来技術】糖質制限全般68【人体実験】 [無断転載禁止]©2ch.net
959 ：病弱名無しさん (ｱｳｱｳｳｰ Sa07-kpOn [106.181.155.27])[]：2017/05/19(金) 16:17:58.29 ID:2oW6XsuAa - In cohort 1, retinoid X receptor-α (RXRA) chr9:136355885+ and endothelial
nitric oxide synthase (eNOS) chr7:150315553+ methylation had independent associations with sex-adjusted childhood fat mass
(exponentiated regression coefficient [β]
17% per SD change in methylation [95% CI 4-31], P = 0.009, n = 64, and β = 20% [9-32], P < 0.001, n = 66, respectively) and %fat mass (β = 10% [1-19], P = 0.023, n = 64 and β =12% [4-20], P = 0.002, n = 66, respectively).
Regression analyses including sex and neonatal epigenetic marks explained >25% of the variance in childhood adiposity.
| - 【未来技術】糖質制限全般68【人体実験】 [無断転載禁止]©2ch.net
960 ：病弱名無しさん (ｱｳｱｳｳｰ Sa07-kpOn [106.181.155.27])[]：2017/05/19(金) 16:19:01.43 ID:2oW6XsuAa - Regression analyses including sex and neonatal epigenetic marks explained >25% of the variance in childhood adiposity.
Higher methylation of RXRA chr9:136355885+, but not of eNOS chr7:150315553+,
was associated with lower maternal carbohydrate intake in early pregnancy, previously linked with higher neonatal adiposity
in this population. In cohort 2, cord eNOS chr7:150315553+ methylation showed no association with adiposity,
but RXRA chr9:136355885+ methylation showed similar associations with fat mass and %fat mass (β = 6% [2-10] and β = 4% [1-7], respectively, both P = 0.002, n = 239).
| - 【未来技術】糖質制限全般68【人体実験】 [無断転載禁止]©2ch.net
961 ：病弱名無しさん (ｱｳｱｳｳｰ Sa07-kpOn [106.181.155.27])[]：2017/05/19(金) 16:19:40.48 ID:2oW6XsuAa - http://diabetes.diabetesjournals.org/content/60/5/1528.long
| - 【未来技術】糖質制限全般68【人体実験】 [無断転載禁止]©2ch.net
962 ：病弱名無しさん (ｱｳｱｳｳｰ Sa07-kpOn [106.181.155.27])[]：2017/05/19(金) 16:20:29.77 ID:2oW6XsuAa - http://diabetes.diabetesjournals.org/content/diabetes/60/5/1528/F1.large.jpg?width=800&height=600&carousel=1
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