RESEARCH DESIGN AND METHODS: We analyzed the dynamics of fasting serum levels of 12 traditional metabolic biomarkers and novel adipokines among 322 participants in the 2-year Dietary Intervention Randomized Controlled Trial (DIRECT) of low-fat, Mediterranean, or low-carbohydrate diets for weight loss. https://www.ncbi.nlm.nih.gov/m/pubmed/22190676/